important matter; matter of great importance; serious affair; major incident; emergency
major incident; major happening; big scandal
take care of yourself; get well soon; God bless you; bless you
with religious zeal; with utmost devotion; take great care of
serious accident; major incident
large enterprise; big business; large undertaking
don't put the trivial ahead of the important; don't sweat the small stuff; don't bother with the details (before embarking on a great enterprise); read the fine print; be careful of the small things (before embarking on a great enterprise)
a small leak can sink a great ship