Verb (5-dan, う, intransitive)
1. to mind; to care about; to be concerned about; to have a regard for
服が濡れるのも構わず、雨の中を走った。Not caring that my clothes got wet, I ran through the rain.
2. to be an issue; to matter; to create inconvenience
それさえ守れば何をやっても構わない。As long as you keep that, you can do whatever you want.
Verb (5-dan, う, transitive)
Usually written in kana
3. to keep company; to care for; to look after; to entertain; to pay attention to; to spend time with
Verb (5-dan, う, intransitive)
4. to interfere with; to meddle in
Verb (5-dan, う, transitive)
5. to tease
6. to banish; to prohibit