1. unwell; in a bad state; out of sorts; in a bad way
また具合が悪くなった?Are you feeling unwell again?
2. not working properly; out of order
3. inconvenient; troublesome
とはいえ、今日は自転車なので乗りながら飲むのも具合が悪い。That said, I'm on my bike today, so drinking while riding isn't convenient either.
4. uncomfortable; awkward
5. indecent; obscene