fate; destiny (esp. as a mysterious force that binds two people together); relationship (e.g. between two people); bond; family ties; affinity; opportunity
to cut; to cut through; to sever (connections, ties); to turn off (e.g. the light); to terminate (e.g. a conversation); to hang up (the phone); to punch (a ticket)
Examples (2 in total)
どうやったら彼と縁を切ることが出来るだろうか。
How can I get rid of him?
トムはマフィアと縁を切って人生をやり直す決意をした。
Tom made the decision to cut ties with the mafia and start life over.