1. very; greatly; terribly; awfully
皆さんには、大変お世話になりました。I have been greatly indebted to all of you.
2. immense; enormous; great
3. serious; grave; dreadful; terrible
本当に大変なことだからな。It's a truly serious matter, you know.
4. difficult; hard; challenging
子供の相手って大変そうだね。Taking care of children seems tough.
5. major incident; disaster