1. to condemn; to blame; to criticize; to criticise; to reproach; to accuse
それでずっと自分を責めているんだ。And so I have been blaming myself all along.
2. to urge; to press; to pester
早くお金を返せと毎日責められている。I'm pressed every day to hurry up and pay the money back.
3. to torture; to torment; to persecute
4. to break in (a horse)