1. there's no (other) way
こうなったら、自分でやるより仕方ない。At this point, there's no other way but to do it myself.
2. cannot be helped; unavoidable; inevitable; (there's) nothing one can do; having no choice
だが、やってしまったものは仕方ない。But there is nothing to be done about what has already been done.
3. it's no use (doing); pointless; useless; no good; insufficient; not enough
oft. as 〜ても仕方ない
全員で行っても仕方なくないか？Isn't it pointless for everyone to go?
4. hopeless (person); annoying; troublesome; awful
本当に仕方ない子だね。You really are a hopeless kid.
5. cannot stand it; unbearable; cannot help (doing, feeling); dying (to do)
as 〜て仕方ない or 〜で仕方ない
夢じゃないってわかっているのに、夢だと思いたくて仕方ない。Even though I know it isn't a dream, I can't help wanting to believe it is.