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It is an expression full of anguish.

The anguish was endless.

Passion creates suffering.

The suffering must have been that much greater.

Why is life so full of suffering?

He'll have many hardships to go through in the future.

There is no sign of anguish over reality on that face.

The newspaper told of the mother's anguish at the death of her son.

And I felt I could see deep anguish and grief in his eyes.

The pain caused by love is much sweeter than any pleasure.